Valizadeh, H. and Zakeri, P. and Barzegar-Jalali, M. and Mohammadi, G. and Danesh, A. and Adibkia, K. and Nokhodchi, A. (2007) Preparation and characterization of solid dispersions of piroxicam with hydrophillic carriers. Drug Development and Industrial Pharmacy, 33 (1). pp. 45-56. ISSN 0363-9045.
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The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit® E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit® E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit® E100.
|Uncontrolled keywords:||piroxicam; solid dispersion; coprecipitate; coevaporate; X-ray diffraction; FT-IR spectroscopy; dissolution|
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Ali Nokhodchi|
|Date Deposited:||14 Jul 2008 09:29|
|Last Modified:||08 May 2012 11:22|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/10169 (The current URI for this page, for reference purposes)|
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