Piroxicam Nanoparticles for Ocular Delivery: Physicochemical Characterization and Implementation in Endotoxin-induced Uveitis

Adibkia, K. and Shadbad, M.R.S. and Nokhodchi, A. and Javadzadeh, A.R. and Barzegar-Jalali, M. and Barar, J. and Mohammadi, G. and Omidi, Y. (2007) Piroxicam Nanoparticles for Ocular Delivery: Physicochemical Characterization and Implementation in Endotoxin-induced Uveitis. Journal of Drug Targeting, 15 (6). pp. 407-416. ISSN 1061-186X . (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1080/10611860701453125

Abstract

To investigate the anti-inflammatory impacts of piroxicam nanosuspension, in the current investigation, piroxicam:Eudragit wRS100 nanoformulations were used to control inflammatory symptoms in the rabbits with endotoxin-induced uveitis (EIU). The nanoparticles of piroxicam:EudragitwRS100 was formulated using the solvent evaporation/extraction technique. The morphological and physicochemical characteristics of nanoparticles were studied using particle size analysis, X-ray crystallography, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). Drug release profileswere examined by fitting the data to the most common kineticmodels. Selected nanosuspensionswere used to assess the anti-inflammatory impacts of piroxicamnanoparticles in the rabbitswithEIU.Themajor symptoms of EIU(i.e. inflammation and leukocytes numbers in the aqueous humor) were examined. All the prepared piroxicam formulations using EudragitwRS100 resulted in a nano-range size particles and displayed spherical smooth morphology with positively charged surface, however, the formulated particles of drug alone using same methodology failed to manifest such characteristics. The EudragitwRS100 containing nanoparticles displayed lower crystallinity than piroxicam with no chemical interactions between the drug and polymermolecules. Kinetically, the release profiles of piroxicam from nanoparticles appeared to fit best with the Weibull model and diffusion was the superior phenomenon. The in vivo examinations revealed that the inflammation can be inhibited by the drug:polymer nanosuspension more significantly than themicrosuspension of drug alone in the rabbitswith EIU.Upon these findings,we propose that the piroxicam:EudragitwRS100 nanosuspensionsmay be considered as an improved ocular delivery system for locally inhibition of inflammation.

Item Type: Article
Uncontrolled keywords: endotoxin-induced uveitis; Eudragit (R) RS100; nanomedicines; nanotechnology; piroxicam; ocular delivery systems
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 02 Aug 2008 12:44
Last Modified: 14 Jan 2010 14:39
Resource URI: http://kar.kent.ac.uk/id/eprint/10133 (The current URI for this page, for reference purposes)
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