Hansen, J.A. and Sumbayev, V. and Gothelf, K.V. (2007) An electrochemical sensor based on the human estrogen receptor ligand binding domain. NANO Letters, 7 (9). pp. 2831-2834. ISSN 1530-6984 . (The full text of this publication is not available from this repository)
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Three different conformations of the ligand binding domain of the human estrogen receptor (ER-LBD) are observed for the native state when binding an agonist and when binding an antagonist. By conjugating ER-LBD conformation specific peptides to CdS nanoparticles, the three different states can be identified by anodic stripping voltarnmetry. This electrochemical sensor can detect and distinguish the binding of different ligands to the human estrogen receptor.
|Divisions:||Faculties > University wide - Teaching/Research Groups|
|Depositing User:||Vadim Sumbayev|
|Date Deposited:||18 Jul 2008 14:08|
|Last Modified:||14 Jan 2010 14:38|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/10056 (The current URI for this page, for reference purposes)|