Sumbayev, V. and Yasinksa, I.M. (2006) Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection. Scandinavian Journal of Immunology, 63 (6). pp. 391-400. ISSN 0300-9475.
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Mitogen-activated protein (MAP) kinase cascades are multifunctional signalling networks that influence cell growth, differentiation, apoptosis and cellular responses to stress. Apoptosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase that triggers apoptogenic kinase cascade leading to the phosphorylation/activation of c-Jun N-terminal kinases (JNK) and p38-MAP kinase, which are responsible to induce apoptotic cell death. This pathway plays a pivotal role in the transduction of signals from different apoptotic stimuli. Recently, it has become evident that ASK1 and its downstream pathway are employed in the transduction of signals from Toll-like receptors (TLR) – multistep processes that interfere with different intracellular signalling pathways. TLR are the key proteins that allow mammals to detect pathogens and mediate innate immune responses. In addition, ASK1 and its downstream pathway play a target role in the regulation of apoptosis in some cases of viral infection – AIDS, influenza, hepatitis C and others. In the present review, we summarize current knowledge about the role of ASK1 and its downstream pathway in innate immune responses and viral infection.
|Divisions:||Faculties > University wide - Teaching/Research Groups|
|Depositing User:||Vadim Sumbayev|
|Date Deposited:||16 Mar 2009 11:35|
|Last Modified:||14 Jan 2010 14:38|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/10047 (The current URI for this page, for reference purposes)|
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