Jouyban, A. and Fakhree, M.A.A. and Ghafourian, T. and Saei, A.A. and Acree, W.E. (2008) Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model – effect of solute structure. Pharmazie, 63 (2). pp. 113-121. ISSN 0031-7144 .
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Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem1 software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being 13%.
Q Science > QD Chemistry
|Divisions:||Faculties > Science Technology and Medical Studies > Medway School of Pharmacy|
|Depositing User:||Taravat Ghafourian|
|Date Deposited:||18 Mar 2009 18:28|
|Last Modified:||14 Jan 2010 14:38|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/10041 (The current URI for this page, for reference purposes)|
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