Jouyban, A. and Fakhree, M.A.A. and Ghafourian, T. and Saei, A.A. and Acree, W.E. (2008) Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model – effect of solute structure. Pharmazie, 63 (2). pp. 113-121. ISSN 0031-7144 .
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| Official URL http://dx.doi.org/10.1691/ph.2008.7670 |
Abstract
Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem1 software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being 13%.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | Faculties > Science Technology and Medical Studies > Medway School of Pharmacy |
| Depositing User: | Taravat Ghafourian |
| Date Deposited: | 18 Mar 2009 18:28 |
| Last Modified: | 14 Jan 2010 14:38 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/10041 (The current URI for this page, for reference purposes) |
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