Skip to main content

Factors affecting the morphology of benzoyl peroxide microsponges

Nokhodchi, Ali, Jelvehgari, Mitra, Siahi, Mohammad Reza, Mozaffari, M. Reza (2007) Factors affecting the morphology of benzoyl peroxide microsponges. Micron, 38 (8). pp. 834-840. ISSN 0968-4328. (doi:10.1016/j.micron.2007.06.012) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:10038)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/j.micron.2007.06.012

Abstract

Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation. It has been shown that encapsulation and controlled release of BPO could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The aim of the present investigation was to design and formulate an appropriate encapsulated form of BPO, using microsponge technology, and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Benzoyl peroxide particles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol (PVA). Different concentrations of BPO microsponges were incorporated in lotion formulations and the drug release from these formulations were studied.

The SEM micrographs of the BPO microsponges enabled measurement of their size and showed that they were spherical and porous. Results showed that the morphology and particle size of microsponges were affected by drug:polymer ratio, stirring rate and the amount of emulsifier used. The results obtained also showed that an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from the

microsponges. The release data showed that the highest and the lowest release rates were obtained from lotions containing plain BPO particles and BPO microsponges with the drug:polymer ratio of 13:1, respectively. The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion.

Item Type: Article
DOI/Identification number: 10.1016/j.micron.2007.06.012
Uncontrolled keywords: benzoyl peroxide; microsponge; release kinetics; morphology; scanning electron microscopy
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Ali Nokhodchi
Date Deposited: 28 Jul 2008 11:47 UTC
Last Modified: 16 Nov 2021 09:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/10038 (The current URI for this page, for reference purposes)

University of Kent Author Information

Nokhodchi, Ali.

Creator's ORCID:
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.