Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species.

Sumbayev, Vadim V. and Yasinska, Inna M. (2005) Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Archives of Biochemistry and Biophysics, 436 (1). pp. 406-412. ISSN 0003-9861 . (The full text of this publication is not available from this repository)

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Abstract

Mitogen-activated protein (MAP) kinase signaling cascades are multi-functional signaling networks that influence cell growth, differentiation, apoptosis, and cellular responses to stress. Apoptosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase that triggers apoptogenic kinase cascade leading to the phosphorylation/activation of c-Jun N-terminal kinases and p38-MAP kinase, which are responsible for inducing apoptotic cell death. This pathway plays a pivotal role in transduction of signals from different apoptotic stimuli. In the present review, we summarized the recent evidence concerning MAP kinase-dependent apoptotic pathway and its regulation in the mammalian cells and organism in vivo. We have shown that the key messengers of regulation of this pathway are the reactive oxygen and nitrogen species. The role of protein oxidation and S-nitrosation in induction of apoptotic cell death via ASK1 is discussed. Also we have outlined other recently discovered signal transduction processes involved in the regulation of ASK1 activity and downstream pathway. (c) 2005 Elsevier Inc. All rights reserved.

Item Type: Review
Uncontrolled keywords: apoptosis; cancer; MAP kinase cascades; reactive oxygen and nitrogen species; hypoxia
Subjects: Q Science
Divisions: Faculties > University wide - Teaching/Research Groups
Depositing User: Vadim Sumbayev
Date Deposited: 02 Apr 2009 20:19
Last Modified: 03 Jul 2014 15:03
Resource URI: http://kar.kent.ac.uk/id/eprint/10034 (The current URI for this page, for reference purposes)
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